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Our genes dictate who develops an allergy

Whether or not you develop an allergy is largely dependent upon genetic factors. This is the main finding of a study recently published in EBioMedicine, just in time for World Allergy Week. The study was supervision of Winfried F. Pickl from MedUni Vienna’s Institute of Immunology. The Vienna researchers were able to show that the gene HLA-DR1 and allergen-specific, reactive T-cells play a major role in the development of an allergy to mugwort, for example – assuming, of course, that one is exposed to the source of the allergen.

It has long been suspected that HLA molecules are generally very significant in autoimmune diseases, chronic infections and allergies. In the recent study, the MedUni Vienna researchers demonstrated for the first time that, in four mouse models, only mice with the HLA-DR1 gene were capable of developing an allergy to mugwort. If, at the same time, allergen-specific, reactive T-cells outnumbered regulatory T-cells, “the result was an explosive attack of asthma and formation of pathogenic, allergen-specific immunoglobulin E,” explains Pickl. The mugwort allergens were administered via the airways, as would normally occur in humans.

Such accurate proof could only be provided, because the MedUni Vienna research group used so-called humanised mice. Pickl explains: “These are animals that carry a human T-cell receptor specific to the allergen and that also have human HLA molecules (note: in this case HLA-DR1) on their antigen-presenting cells. Our new model is therefore the first model to reflect the human situation.”

The MedUni Vienna immunologists were further able to show that giving the T-cell growth factor interleukin-2 helps to stimulate regulatory T-cells, preventing the development of allergic asthma.

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