A laboratory test developed by a study group from MedUni Vienna can determine whether COVID-19 patients develop protective antibodies after having the disease. Scientists from MedUni Vienna’s Institute of Pathophysiology and Allergy Research discovered that only around 60% of patients who have had COVID-19 and recovered from it develop protective antibodies and, for the first time, they were able to show that some antibodies even assist the virus by augmenting it to the cells of the host. The results have recently been published in the leading journal Allergy.
The team, led by Rudolf Valenta, developed an ELISA laboratory test to identify patients who had developed protective antibodies after COVID-19 infection. This showed that only 60% of patients convalescing from COVID-19 developed antibodies that inhibit the interaction of the SARS-CoV-2 receptor-binding domain (RBD) with ACE2. The ACE2 (angiotensin converting enzyme 2) receptor for SARS-CoV-2 occurs predominantly in the respiratory tract and other organs affected by the virus. “The positive outcome is that we now have a test that can identify antibodies and show whether people who have already been infected have protective immunity or not.”
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