Personal Health

Can you take after a vaccination pain relievers such as Ibuprofen or ACE?

May be you should shortly after a vaccination pain relievers such as Ibuprofen, ASA (acetylsalicylic acid) or Paracetamol better not take. Also on a preventive use , should you might rather do without. Because the pain meds can weaken the Impfeffekt under certain circumstances.

Active ingredients such as Ibuprofen, aspirin or Paracetamol, are so-called COX-inhibitors. They relieve pain and fever by inhibiting in the body, the enzymes COX1 and COX2, and thereby prevent pain – and inflammation-mediating neurotransmitters are released.

The enzyme COX-2 also plays a role in vaccinations: When the immune system as a reaction to the vaccination becomes active, it requires COX2, using the B-lymphocytes (a type of white blood cells) to make antibodies. By the intake of painkillers in the short to the vaccination point around the Impfeffekt so may be lower than desired, because the excitation of the fragments in the vaccine are fewer antibodies to be produced.

Whether the inhibitory effect on the immune response but so far, that a vaccine will be completely ineffective, according to the current state of the research does not say. That such pain killers at the end, perhaps, no protection is provided, to hold various doctors for unlikely.


Information for pain and stress reduction to Vaccinate. Online information of the Robert Koch-Institute: (status: 23.8.2018)

Over-the-counter pain relievers safe to apply. Online information of the Institute for quality and efficiency in health care: (status: 26.7.2017)

Saleh, E., et al.: Effect of antipyretic analgesics on immune responses to vaccination. Human Vaccines & Immuno-Therapeutics, No. 12, Iss. 9, PP 2391-2402 (September 2016)

Weaknesses the pain of the Vaccination? Online information of (dated: 18.5.2010)

Vaccinations – Disturbing Pain. Online information is the Foundation of the test: (updated: 28.1.2010)were

Impfeffekt can be reduced by some medicines significantly. Online information of the German society for pneumology and respiratory medicine: (status: 28.11.2009)

Prymula, R., et al.: Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. The Lancet, No. 374, Iss. 9698, pp. 1339-1350 (October 2009)

Bancos, S., et al.: Ibuprofen and other widely used nonsteroidal anti-inflammatory drugs inhibit antibody production in human cells. Cellular Immunology, No. 258, Iss. 1, PP 18-28 (2009)

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