Health News

Manipulating stress response in cells could help slow down aging: Findings from lab studies on roundworms could open the door to therapies for age-related disorders

Scientists at Nanyang Technological University, Singapore (NTU Singapore) have found that a stress response in cells, when ‘switched on’ at a post-reproductive age, could be the key to slow down ageing and promote longevity.

In lab experiments on a type of roundworm that shares similarities with humans, the NTU Singapore team found that switching on this stress response in aged worms by feeding them a high-glucose diet extended their lifespan as compared to worms fed a normal diet.

This is the first time a link between this stress response and ageing has been uncovered, said the NTU team of their findings published on 19 October in Nature Communications.

While further studies are needed to gain a deeper understanding of this link, the scientists said their findings open the door to the development of therapies that could delay the onset or even tackle age-related disorders such as cancer, dementia, and stroke.

Cell biologist and study lead Associate Professor Guillaume Thibault from the NTU School of Biological Sciences said: “Ageing is a critical risk factor for a variety of human pathologies, from metabolic diseases such as diabetes to cancer and neurodegenerative diseases. From a public health perspective, determining the cellular pathways that underpin the ageing process could take us one step closer to developing novel therapeutic strategies to treat age-related disorders.

“While our study found that a high-glucose diet could be useful to slow down ageing and promote longevity in aged worms, we are not recommending that the aged population should now turn to a high-sugar diet. What this study does show is that triggering certain stress responses in cells may translate to longevity, and that activating this stress response with a drug might be critical to decelerate cellular ageing.”

Aside from showing that the effect of manipulating this stress response in aged worms, the NTU scientists also showed that the same response, when ‘switched off’ in young worms fed a high-glucose diet, helped them to live longer than worms on a normal diet.

Source: Read Full Article