Gum diseases are among the most common chronic human diseases, affecting between 20 to 50% of people worldwide. They happen when plaque, a sticky film of bacteria, builds up on teeth. The earliest stages of gum disease are treatable and reversible (gingivitis). But some people develop a chronic destructive form of gum disease, which is irreversible. This disease progresses to tooth loss. A growing body of evidence shows that gum disease can also make people more likely to develop other serious health conditions.
Here are a few of the common health conditions linked to gum disease and how they are connected.
1. Alzheimer’s disease
Several large studies and meta-analyses agree that moderate or severe gum disease is significantly associated with dementia. For example, one study showed suffering from chronic gum disease for ten years or more was associated with a 70% higher risk of developing Alzheimer’s than those without. Research has also shown a link between gum disease and a sixfold decline in cognitive ability.
Initially, it was thought bacteria were directly responsible for this link. P. gingivalis, bacteria common in chronic gum disease, was found in the brains of people who had died of Alzheimer’s disease. Toxic bacterial enzymes called gingipains were also found, which are thought to worsen gum disease by preventing the immune response from turning off and hence prolonging inflammation.
However, it’s not certain whether bacteria in the brain, a modified immune response or other factors—such as damage from systemic inflammation—explain the link. But taking care of your oral health could be one way to reduce the risk of Alzheimer’s disease.
2. Cardiovascular disease
Cardiovascular disease is also firmly associated with gum disease.
In a large study of over 1,600 people aged over 60, gum disease was linked with an almost 30% higher risk of first heart attack. This link even persisted after researchers adjusted for other conditions (such as diabetes and asthma), or lifestyle habits (such as smoking status, education and marriage) that are known to increase a person’s risk of a heart attack.
More recently, studies have also shown that systemic inflammation caused by chronic gum disease causes the body’s stem cells to produce a hyper-responsive group of neutrophils (a type of early defense white blood cell). These cells may damage the lining of arteries by damaging the cells that line the arteries—triggering the build-up of plaques.
3. Type 2 diabetes
Gum disease is a known complication of type 2 diabetes, and chronic gum disease increases the risk of developing type 2 diabetes.
The processes that link the two diseases are the focus of much research, and it’s likely that inflammation caused by each condition affects the other. For instance, type 2 diabetes raises the risk of gum disease by increasing inflammation in the gums. Gum disease has also been shown to contribute to impaired insulin signaling and insulin resistance—which can both exacerbate type 2 diabetes.
Several clinical trials have shown an intensive dental cleaning can improve blood sugar control in diabetic patients for several months, further showing the links between the two diseases.
Gum disease is also linked to a greater risk of developing many types of cancer. For instance, patients who reported having a history of gum disease were shown to have a 43% greater risk of esophageal cancer, and a 52% greater risk of stomach cancer. Other research has also reported people with chronic gum disease had a between 14–20% higher risk of developing any type of cancer. The same study also showed a 54% higher risk of pancreatic cancer.
It’s not clear why this relationship exists. Some think it has to do with inflammation, which is a factor in both gum disease and cancer. Inflammation disrupts the environment that cells need to stay healthy and function properly and is a factor in the progression of both gum disease and tumor growth.
Improving gum health
Gum disease is preventable and reversible in the early stages.
While some risk factors for gum disease can’t be changed (such as your genetics), you can change your lifestyle to reduce your overall risk. For example, eating less sugar, avoiding tobacco and alcohol and reducing stress can all help. It’s also important to know that certain medications (such as some antidepressants and hypertension drugs) may lower saliva production, which can increase your risk of gum disease. People taking these medicines need to take extra precautions, such as using special gels or sprays to increase saliva production, or making sure to take extra care while brushing their teeth.
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